A major limitation of conventional microscopes is the penetration depth in turbid media (e.g tissue, thick cells). It is known that turbid media scatter the incoming light, resulting in a messy image after the sample. But there is clever way to undo the effect of scattering medium by simply modulating the incoming light using a Spatial Light Modulator(SLM) or an equivalent device to adjust the wavefront.
Some recent articles on Imaging through turbid media:
Scattered light fluorescence Microscopy: imaging through turbid layers, Optics Letters
Focusing coherent light through opaque strongly scattering media, Optics Letters
Exploiting disorder for perfect focusing, Nature Photonics
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